The CHRNA6 Polyclonal Antibody (CAB8470) is a vital tool for research involving the CHRNA6 protein, which is a member of the nicotinic acetylcholine receptor family. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. It specifically binds to the CHRNA6 protein, enabling precise detection and analysis in a variety of cell types.CHRNA6 is involved in neurotransmission and has been implicated in various neurological disorders such as epilepsy, nicotine addiction, and cognitive impairments.
Research on the CHRNA6 protein is crucial for understanding its role in these conditions and developing targeted therapies. The CHRNA6 Polyclonal Antibody is an essential tool for studying the function and regulation of CHRNA6, making it a valuable asset in neuroscience and pharmacology research.
Product Name:
CHRNA6 Rabbit Polyclonal Antibody
SKU:
CAB8470
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 350-440 of human CHRNA6 (NP_004189.1).
This gene encodes an alpha subunit of neuronal nicotinic acetylcholine receptors. These receptors consist of five subunits and function as ion channels involved in neurotransmission. The encoded protein is a subunit of neuronal nicotinic acetylcholine receptors that mediate dopaminergic neurotransmission and are activated by acetylcholine and exogenous nicotine. Alternatively spliced transcript variants have been observed for this gene. Single nucleotide polymorphisms in this gene have been associated with both nicotine and alcohol dependence.
Purification Method:
Affinity purification
Gene ID:
8973
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CHRNA6 antibody (CAB8470) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
