The CHRNA5 Polyclonal Antibody (CAB1741) offered by Assay Genie is a valuable tool for researchers studying the CHRNA5 gene, which encodes a subunit of the nicotinic acetylcholine receptor. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the CHRNA5 protein, this antibody facilitates the detection and analysis of this receptor subunit in various cell types, making it ideal for research in neurobiology, addiction, and related fields.The CHRNA5 gene is of particular interest in studies related to nicotine addiction, as variations in this gene have been associated with smoking behavior and increased susceptibility to nicotine dependence.
By better understanding the role of CHRNA5 in nicotine response and addiction pathways, researchers may be able to develop more effective strategies for smoking cessation and addiction treatment.Overall, the CHRNA5 Polyclonal Antibody (CAB1741) provides a valuable tool for researchers investigating the molecular mechanisms underlying nicotine addiction and related disorders, with the potential to contribute to the development of targeted therapies for smoking cessation and addiction interventions.
Product Name:
CHRNA5 Rabbit Polyclonal Antibody
SKU:
CAB1741
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 23-240 of human CHRNA5 (NP_000736.2).
The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2).
Purification Method:
Affinity purification
Gene ID:
1138
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CHRNA5 antibody (CAB1741) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
