The CHRM4 Polyclonal Antibody (CAB2866) is a vital tool for research involving the CHRM4 protein, a key player in the cholinergic signaling pathway. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for various applications such as Western blotting.CHRM4, also known as the muscarinic acetylcholine receptor M4, is involved in mediating the effects of acetylcholine on neuronal and non-neuronal cells. Its role in regulating various physiological processes, including neurotransmission and smooth muscle contraction, makes it a promising target for studies on neurological disorders and muscle disorders.
By utilizing the CHRM4 Polyclonal Antibody, researchers can further investigate the function and expression of CHRM4 in different cell types and tissues, aiding in the development of potential therapeutics targeting the cholinergic system. The antibody's ability to specifically bind to CHRM4 protein enables precise detection and characterization, making it an indispensable tool for studies in neuroscience and pharmacology.
Product Name:
CHRM4 Rabbit Polyclonal Antibody
SKU:
CAB2866
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 261-319 of human CHRM4 (NP_000732.2).
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition.
Purification Method:
Affinity purification
Gene ID:
1132
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of NIH/3T3 cells, using CHRM4 antibody (CAB2866).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
