The CHRM2 Polyclonal Antibody (CAB1567) is a vital tool for researchers studying the CHRM2 protein, a member of the muscarinic acetylcholine receptor family. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been rigorously validated for Western blot applications. By binding specifically to the CHRM2 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it a valuable asset in immunology and neuroscience research.The CHRM2 protein is known for its involvement in regulating various physiological processes, including synaptic transmission, smooth muscle contraction, and cognitive function.
Dysfunction of the CHRM2 receptor has been implicated in neurological disorders such as Alzheimer's disease and schizophrenia, making it an important target for therapeutic interventions. By understanding the role of CHRM2 in these conditions, researchers can develop novel treatment strategies aimed at restoring proper receptor function and improving patient outcomes.Overall, the CHRM2 Polyclonal Antibody (CAB1567) offers researchers a reliable tool for investigating the physiological and pathological roles of the CHRM2 receptor, paving the way for advancements in drug development and personalized medicine.
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
1129
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Muscarinic AChR M2 (ACM2) antibody (CAB1567) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
