The CHRM1 Polyclonal Antibody (CAB16819) is a valuable tool for researchers studying the CHRM1 protein, a member of the muscarinic acetylcholine receptor family. This antibody, derived from rabbit serum, is highly specific for human samples and is validated for use in Western blot applications. By binding to the CHRM1 protein, the antibody enables accurate detection and analysis in a variety of cell types, making it ideal for studies in neurology, pharmacology, and drug development.CHRM1 is an important receptor in the central and peripheral nervous systems, where it plays a crucial role in mediating the effects of acetylcholine.
Dysregulation of CHRM1 has been implicated in various neurological disorders, including Alzheimer's disease, schizophrenia, and Parkinson's disease. By studying the function and expression of CHRM1, researchers can gain insights into the underlying mechanisms of these conditions and potentially identify new therapeutic targets. Overall, the CHRM1 Polyclonal Antibody is a valuable tool for investigating the role of CHRM1 in neurological disorders and advancing our understanding of acetylcholine signaling pathways in the brain.
Product Name:
CHRM1 Rabbit Polyclonal Antibody
SKU:
CAB16819
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CHRM1 (NP_000729.2).
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13.
Purification Method:
Affinity purification
Gene ID:
1128
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CHRM1 Rabbit pAb (CAB16819) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
