The CHRM1 Polyclonal Antibody (CAB1598) is a valuable tool for researchers studying the CHRM1 receptor, a member of the muscarinic acetylcholine receptor family implicated in various physiological processes. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the CHRM1 protein, this antibody allows for accurate detection and analysis in a range of cell types, making it an excellent choice for studies in neuroscience, pharmacology, and drug discovery.The CHRM1 receptor is a G protein-coupled receptor that plays a crucial role in mediating the effects of acetylcholine in the central and peripheral nervous systems.
Its involvement in processes such as neurotransmission, muscle contraction, and memory make it a promising target for research into conditions like Alzheimer's disease, epilepsy, and schizophrenia. Investigating the function of CHRM1 with the help of this antibody can provide valuable insights into the underlying mechanisms of these disorders and inform the development of novel therapeutic strategies.
Product Name:
CHRM1 Rabbit Polyclonal Antibody
SKU:
CAB1598
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 251-350 of human CHRM1 (NP_000729.2).
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13.
Purification Method:
Affinity purification
Gene ID:
1128
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CHRM1 Rabbit pAb (CAB1598) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
