Chrm1 Antibody (PACO25749)
- SKU:
- PACO25749
- Product Type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
Chrm1 Antibody (PACO25749)
The CHRM1 Antibody (PAC025749) is a valuable tool for researchers studying the muscarinic acetylcholine receptor M1 (CHRM1), a key player in mediating neurotransmission and neuromodulation in the central nervous system. This polyclonal antibody, generated in rabbits, is highly specific to human samples and is validated for use in various applications, including Western blot and immunohistochemistry.CHRM1 is known for its role in regulating cognitive functions, memory, and smooth muscle contraction. Dysregulation of this receptor has been implicated in neurodegenerative diseases, such as Alzheimer's disease, making it a promising target for drug development and therapeutic interventions.
The CHRM1 Antibody enables researchers to detect and analyze the expression of CHRM1 protein in different cell types and tissues, providing valuable insights into its function and potential implications in various pathological conditions. Its high reactivity and specificity make it an essential tool for studies in neuroscience, pharmacology, and neurology research.
| Antibody Name: | Chrm1 Antibody (PACO25749) |
| Antibody SKU: | PACO25749 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
| Species Reactivity: | Rat |
| Immunogen: | Recombinant Rat Muscarinic acetylcholine receptor M1 protein (210-366AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot Positive WB detected in: Rat brain tissue All lanes: Chrm1 antibody at 5.5µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 52 kDa Observed band size: 52 kDa . |
| Background: | The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. |
| Synonyms: | Muscarinic acetylcholine receptor M1, Chrm1, Chrm-1 |
| UniProt Protein Function: | mAChR m1: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM1 sub-subfamily.Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integralCellular Component: asymmetric synapse; cell junction; dendrite; integral to plasma membrane; nerve terminal; plasma membrane; postsynaptic density; postsynaptic membrane; synapseMolecular Function: drug binding; G-protein coupled acetylcholine receptor activityBiological Process: acetylcholine receptor signaling, muscarinic pathway; cognition; muscarinic acetylcholine receptor, adenylate cyclase inhibiting pathway; muscarinic acetylcholine receptor, phospholipase C activating pathway; neuromuscular synaptic transmission; positive regulation of ion transport; regulation of locomotion; regulation of vascular smooth muscle contraction; saliva secretion; synaptic transmission, cholinergic |
| UniProt Protein Details: | |
| NCBI Summary: | plays a role in acetylcholine receptor signaling and neuromuscular synaptic transmission [RGD, Feb 2006] |
| UniProt Code: | P08482 |
| NCBI GenInfo Identifier: | 18249941 |
| NCBI Gene ID: | 25229 |
| NCBI Accession: | NP_542951.1 |
| UniProt Secondary Accession: | P08482 |
| UniProt Related Accession: | P08482 |
| Molecular Weight: | 51,369 Da |
| NCBI Full Name: | muscarinic acetylcholine receptor M1 |
| NCBI Synonym Full Names: | cholinergic receptor, muscarinic 1 |
| NCBI Official Symbol: | Chrm1Â Â |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | muscarinic acetylcholine receptor M1 |
| UniProt Protein Name: | Muscarinic acetylcholine receptor M1 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Microtubule-associated protein |
| UniProt Gene Name: | Chrm1Â Â |
| UniProt Entry Name: | ACM1_RAT |
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