The CHRDL Polyclonal Antibody (CAB17571) is a essential tool for researchers studying the role of CHRDL, a protein involved in the regulation of bone formation and developmental processes. This antibody, generated in rabbits, shows high specificity and sensitivity for detecting CHRDL in human samples, making it ideal for use in Western blot analyses. By specifically binding to CHRDL, researchers can investigate its functions in various cell types and gain insights into its potential roles in skeletal development and disease.CHRDL, also known as chordin-like protein, is a key player in the regulation of bone morphogenetic proteins (BMPs), which are essential for embryonic development and bone formation.
Dysregulation of CHRDL has been implicated in skeletal abnormalities and disorders such as osteoporosis and skeletal dysplasias. By understanding the mechanisms through which CHRDL modulates BMP signaling, researchers can potentially develop targeted therapies for bone-related diseases and disorders.Overall, the CHRDL Polyclonal Antibody (CAB17571) provides a valuable tool for researchers interested in unraveling the complexities of CHRDL biology and its implications for skeletal development and disease. Its high specificity and sensitivity make it a reliable choice for studies in the fields of developmental biology, bone biology, and musculoskeletal research.
Product Name:
CHRD Rabbit Polyclonal Antibody
SKU:
CAB17571
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 686-955 of human CHRD (NP_003732.2).
This gene encodes a secreted protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes. The encoded protein may also have roles in organogenesis and during adulthood. It has been suggested that this gene could be a candidate gene for Cornelia de Lange syndrome. Reduced expression of this gene results in enhanced bone regeneration. Alternative splicing results in multiple transcript variants. Other alternative splice variants have been described but their full length sequence has not been determined.
Purification Method:
Affinity purification
Gene ID:
8646
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CHRD Rabbit pAb (CAB17571) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
