CHMP4B Rabbit Polyclonal Antibody (CAB7402)
- SKU:
- CAB7402
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
Product Name: | CHMP4B Rabbit Polyclonal Antibody |
SKU: | CAB7402 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-224 of human CHMP4B (NP_789782.1). |
Sequence: | MSVF GKLF GAGG GKAG KGGP TPQE AIQR LRDT EEML SKKQ EFLE KKIE QELT AAKK HGTK NKRA ALQA LKRK KRYE KQLA QIDG TLST IEFQ REAL ENAN TNTE VLKN MGYA AKAM KAAH DNMD IDKV DELM QDIA DQQE LAEE ISTA ISKP VGFG EEFD EDEL MAEL EELE QEEL DKNL LEIS GPET VPLP NVPS IALP SKPA KKKE EEDD DMKE LENW AGSM |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | SNF7; CTPP3; Shax1; CHMP4A; SNF7-2; VPS32B; CTRCT31; Vps32-2; C20orf178; dJ553F4.4; CHMP4B |
Positive Sample: | Mouse spleen |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Late endosome membrane, Peripheral membrane protein, cytosol. |
Calculated MW: | 25kDa |
Observed MW: | 25kDa |
This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts.
Purification Method: | Affinity purification |
Gene ID: | 128866 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |