The CHL1 Polyclonal Antibody (CAB9681) is a valuable tool for research involving CHL1, a cell adhesion molecule that plays a critical role in neural development and synaptic plasticity. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in various applications, including Western blot and immunohistochemistry.CHL1, also known as close homolog of L1, is involved in neuronal migration, axonal guidance, and synaptic connectivity in the central nervous system. Its expression has been associated with neurodevelopmental disorders and neurological diseases, making it an attractive target for research in neuroscience and neurology.
By enabling detection and analysis of CHL1 protein in different cell types and tissues, this antibody is an essential tool for studying the function and regulation of CHL1 in normal and pathological conditions. Its versatility and specificity make it an ideal choice for researchers interested in understanding the mechanisms underlying neural development and function.
Product Name:
CHL1 Rabbit Polyclonal Antibody
SKU:
CAB9681
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 690-950 of human CHL1 (NP_001240316.1).
Cell membrane, Secreted, Single-pass type I membrane protein, extracellular matrix, extracellular space.
Calculated MW:
135kDa
Observed MW:
135kDa
The protein encoded by this gene is a member of the L1 gene family of neural cell adhesion molecules. It is a neural recognition molecule that may be involved in signal transduction pathways. The deletion of one copy of this gene may be responsible for mental defects in patients with 3p- syndrome. This protein may also play a role in the growth of certain cancers. Alternate splicing results in both coding and non-coding variants.
Purification Method:
Affinity purification
Gene ID:
10752
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CHL1 antibody (CAB9681) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
