The Chitotriosidase-1 Polyclonal Antibody (CAB2015) offered by AssayGenie is a valuable tool for researchers studying chitotriosidase-1, an enzyme involved in the degradation of chitin. This antibody, raised in rabbits, is highly specific to human chitotriosidase-1 and has been validated for use in various applications, including Western blotting. Chitotriosidase-1 is known to play a role in the immune system, particularly in the defense against chitin-containing pathogens. It is also implicated in various diseases, such as Gaucher disease, where its levels are increased.
By using the CAB2015 antibody, researchers can detect and analyze chitotriosidase-1 levels in different cell types, furthering our understanding of its function in health and disease.This antibody is a valuable tool for researchers in immunology, infectious diseases, and metabolic disorders, as it allows for accurate detection and visualization of chitotriosidase-1 protein levels. By studying chitotriosidase-1, researchers can potentially uncover new therapeutic targets and treatment strategies for a range of conditions.
Product Name:
CHIT1 Rabbit Polyclonal Antibody
SKU:
CAB2015
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 217-466 of human CHIT1 (NP_003456.1).
Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
1118
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CHIT1 Rabbit pAb (CAB2015) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
