CHIT1 Rabbit Polyclonal Antibody (CAB2015)
- SKU:
- CAB2015
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Frequently bought together:
Description
Product Name: | CHIT1 Rabbit Polyclonal Antibody |
SKU: | CAB2015 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 217-466 of human CHIT1 (NP_003456.1). |
Sequence: | SWEK VTGH NSPL YKRQ EESG AAAS LNVD AAVQ QWLQ KGTP ASKL ILGM PTYG RSFT LASS SDTR VGAP ATGS GTPG PFTK EGGM LAYY EVCS WKGA TKQR IQDQ KVPY IFRD NQWV GFDD VESF KTKV SYLK QKGL GGAM VWAL DLDD FAGF SCNQ GRYP LIQT LRQE LSLP YLPS GTPE LEVP KPGQ PSEP EHGP SPGQ DTFC QGKA DGLY PNPR ERSS FYSC AAGR LFQQ SCPT GLVF SNSC KCCT WN |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 |
Synonyms: | CHI3; CHIT; CHITD; CHIT1 |
Positive Sample: | U-251MG,293T,Mouse spleen,Mouse skeletal muscle |
Conjugate: | Unconjugated |
Cellular Localization: | Lysosome, Secreted. |
Calculated MW: | 52kDa |
Observed MW: | 52kDa |
Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene.
Purification Method: | Affinity purification |
Gene ID: | 1118 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |