The CHI3L1 Polyclonal Antibody (AB10052) is a valuable tool for research involving CHI3L1, a glycoprotein associated with inflammation and tissue remodeling. This rabbit-derived antibody is highly specific for human samples and has been validated for use in Western blot applications. By binding to the CHI3L1 protein, researchers can detect and analyze its expression in various cell types, making it an essential component for studies in immunology, cancer research, and inflammatory conditions.CHI3L1, also known as YKL-40, is involved in various physiological and pathological processes, including tissue repair, inflammation, and cell migration.
Its upregulation has been linked to diseases such as asthma, rheumatoid arthritis, and cancer, making it a potential biomarker for these conditions. Studying the role of CHI3L1 is crucial for understanding its function in disease progression and identifying potential therapeutic targets. Overall, the CHI3L1 Polyclonal Antibody is a valuable tool for researchers seeking to explore the role of CHI3L1 in health and disease, with the potential to uncover new insights into the mechanisms underlying inflammatory conditions and cancer progression.
Product Name:
CHI3L1 Rabbit Polyclonal Antibody
SKU:
CAB11510
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 22-383 of YKL-40/CHI3L1 (NP_001267.2).
Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling.
Purification Method:
Affinity purification
Gene ID:
1116
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using YKL-40/CHI3L1 antibody (CAB11510) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
