The CHI3L1 Polyclonal Antibody (CAB3166) is a valuable tool for research involving CHI3L1, a protein associated with inflammatory responses and tissue remodeling. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to CHI3L1, this antibody enables the detection and analysis of the protein in various cell types, making it an ideal choice for studies in immunology and cancer research.CHI3L1, also known as YKL-40, is a chitinase-like protein that is upregulated in response to inflammation and tissue injury.
Its involvement in processes such as cell proliferation, angiogenesis, and extracellular matrix remodeling makes it a key player in various pathological conditions, including cancer, inflammatory diseases, and neurodegenerative disorders. By studying the role of CHI3L1 in these contexts, researchers can gain insights that may lead to the development of novel therapeutic strategies targeting this protein.
Product Name:
YKL-40/CHI3L1 Rabbit Polyclonal Antibody
SKU:
CAB3166
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 22-383 of YKL-40/CHI3L1 (NP_001267.2).
Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling.
Purification Method:
Affinity purification
Gene ID:
1116
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from THP-1 cells, using YKL-40/CHI3L1 Rabbit pAb (CAB3166) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
