The CHI3L1 Polyclonal Antibody (CAB1723) is a valuable tool for researchers studying CHI3L1, a glycoprotein that plays a key role in various inflammatory processes. This polyclonal antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.CHI3L1, also known as chitinase-3-like protein 1 or YKL-40, is associated with various diseases, including cancer, asthma, and inflammatory disorders. Its expression is often elevated in conditions characterized by inflammation and tissue remodeling, making it a potential biomarker for disease progression and treatment response. By targeting CHI3L1 with this antibody, researchers can detect and analyze its presence in different cell types, providing insights into its functions in disease pathogenesis.
The importance of CHI3L1 in immune response modulation and disease development underscores the relevance of this antibody in immunology and cancer research. By investigating the role of CHI3L1 in various pathological conditions, researchers can gain comprehensive understanding of its mechanisms and potential as a therapeutic target. Unlocking the secrets of CHI3L1 with this polyclonal antibody paves the way for innovative research and discoveries in the field of biomedicine.
Product Name:
YKL-40/CHI3L1 Rabbit Polyclonal Antibody
SKU:
CAB1723
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 22-220 of human YKL-40/CHI3L1 (NP_001267.2).
Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling.
Purification Method:
Affinity purification
Gene ID:
1116
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from THP-1 cells, using YKL-40/CHI3L1 Rabbit pAb (CAB1723) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
