The CHGA Polyclonal Antibody (CAB1668) is a valuable tool for researchers studying chromogranin A, a protein involved in the regulation of the neuroendocrine system. This antibody, generated in rabbits, has high specificity for human samples and has been validated for use in Western blot applications. By targeting the CHGA protein, this antibody allows for the accurate detection and analysis of chromogranin A in various cell types, making it ideal for studies focused on neuroendocrinology and endocrine disorders.Chromogranin A is a key player in the regulation of hormone secretion and neurotransmitter release, making it a crucial target for research into conditions such as diabetes, hypertension, and neuroendocrine tumors.
Understanding the role of CHGA in these processes is essential for developing new diagnostic tools and therapeutic interventions for patients suffering from neuroendocrine-related disorders. The CHGA Polyclonal Antibody provides researchers with a reliable tool to further investigate the functions and mechanisms of chromogranin A in health and disease.
Product Name:
CHGA Rabbit Polyclonal Antibody
SKU:
CAB1668
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 230-380 of human CHGA (NP_001266.1).
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two other peptides, catestatin and chromofungin, have antimicrobial activity and antifungal activity, respectively. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
1113
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CHGA Rabbit pAb (CAB1668) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
