The CHD2 Polyclonal Antibody (CAB13476) is a valuable tool for research involving the CHD2 protein, a key regulator of chromatin remodeling and gene expression. This antibody, generated in rabbits, exhibits high reactivity with human samples and is specifically validated for use in immunofluorescence and immunohistochemistry applications. By targeting the CHD2 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential component for studies in genetics and epigenetics research.
CHD2, a member of the chromodomain helicase DNA-binding protein family, plays a crucial role in maintaining chromatin structure and regulating gene transcription. Dysregulation of CHD2 has been linked to developmental disorders, neurological diseases, and various cancers, highlighting its importance in cellular function and disease pathways. By delving into the mechanisms of CHD2 activity, researchers can gain insights into disease pathology and potentially identify new therapeutic targets for intervention.
Product Name:
CHD2 Rabbit Polyclonal Antibody
SKU:
CAB13476
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 242-501 of human CHD2 (NP_001036037.1).
The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
1106
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunofluorescence analysis of HeLa cells using CHD2 antibody (CAB13476). Blue: DAPI for nuclear staining.
