The CHCHD3 Polyclonal Antibody (CAB8584) is a research tool designed for studying CHCHD3, a protein implicated in mitochondrial function and regulation. This antibody is produced in rabbits and exhibits high reactivity with human samples, making it suitable for use in Western blot applications. By binding specifically to CHCHD3, researchers can detect and analyze the protein in various cell types, providing valuable insights into its role in cellular processes related to mitochondrial biology.CHCHD3 is known to interact with other proteins involved in mitochondrial dynamics and maintenance, suggesting its importance in regulating mitochondrial function. Dysfunction of CHCHD3 has been linked to various diseases, including neurodegenerative disorders and metabolic conditions.
Therefore, exploring the functions and mechanisms of CHCHD3 using the CAB8584 antibody may provide novel insights into the pathogenesis of these diseases and potential therapeutic strategies targeting mitochondrial dysfunction.Overall, the CHCHD3 Polyclonal Antibody is a valuable tool for researchers interested in investigating the role of CHCHD3 in mitochondrial biology and disease pathology. Its high specificity and reactivity make it a reliable choice for studies aimed at elucidating the molecular mechanisms underlying mitochondrial dysfunction and associated pathologies.
Product Name:
CHCHD3 Rabbit Polyclonal Antibody
SKU:
CAB8584
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-227 of human CHCHD3 (NP_060282.1).
The protein encoded by this gene is an inner mitochondrial membrane scaffold protein. Absence of the encoded protein affects the structural integrity of mitochondrial cristae and leads to reductions in ATP production, cell growth, and oxygen consumption. This protein is part of the mitochondrial contact site and cristae organizing system (MICOS). Several transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
54927
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using CHCHD3 Rabbit pAb (CAB8584) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 40s.
