The Chat Polyclonal Antibody (CAB2495) is specifically designed for research involving CD300A, a cell surface molecule known for its role in immune regulation and inhibition of immune responses. This antibody, derived from rabbit immunoglobulins, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to the CD300A protein, this antibody enables detection and analysis in various cell types, making it a valuable tool for studies in immunology and cancer research.CD300A, also referred to as an immune inhibitory receptor, plays a crucial role in immune homeostasis by regulating inflammation and suppressing allergic reactions.
Its involvement in immune response modulation makes it a promising target for research on diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. Through investigating the function of CD300A, researchers can gain insights that may lead to the development of therapies aimed at harnessing or modulating immune activity in these disease contexts.
Product Name:
CHAT Rabbit Polyclonal Antibody
SKU:
CAB2495
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human CHAT (NP_065574.4).
This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform.
Purification Method:
Affinity purification
Gene ID:
1103
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CHAT Rabbit pAb (CAB2495).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
