The CHAF1B Polyclonal Antibody (CAB6259) is a valuable tool for researchers studying the CHAF1B protein, which plays a crucial role in DNA replication and repair processes. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it a reliable choice for Western blot applications.CHAF1B, also known as Chromatin Assembling Factor 1 Subunit B, is essential for maintaining genomic stability and proper cell division. Dysregulation of CHAF1B has been implicated in various diseases, including cancer and developmental disorders.
By targeting CHAF1B with this antibody, researchers can study its function in different cell types and gain insights into its role in disease pathogenesis.With its ability to detect and analyze CHAF1B protein expression, this antibody is a valuable tool for studies in molecular biology, cancer research, and genetics. By understanding the mechanisms underlying CHAF1B activity, researchers can potentially identify new therapeutic targets for diseases associated with dysregulated DNA replication and repair pathways.
Product Name:
p60 CAF1 Rabbit Polyclonal Antibody
SKU:
CAB6259
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 270-559 of human p60 CAF1 (NP_005432.1).
Chromatin assembly factor I (CAF-I) is required for the assembly of histone octamers onto newly-replicated DNA. CAF-I is composed of three protein subunits, p50, p60, and p150. The protein encoded by this gene corresponds to the p60 subunit and is required for chromatin assembly after replication. The encoded protein is differentially phosphorylated in a cell cycle-dependent manner. In addition, it is normally found in the nucleus except during mitosis, when it is released into the cytoplasm. This protein is a member of the WD-repeat HIR1 family and may also be involved in DNA repair.
Purification Method:
Affinity purification
Gene ID:
8208
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using p60 CAF1 Rabbit pAb (CAB6259) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 30s.
