The CHAC1 Polyclonal Antibody (CAB15584) is specifically designed for researchers studying CHAC1, a key enzyme involved in the regulation of redox balance and cellular responses to stress. This antibody, generated in rabbits, is highly sensitive and reacts strongly with human samples, making it an excellent tool for Western blot analysis. By binding to the CHAC1 protein, this antibody enables precise detection and analysis in a variety of cell types, offering valuable insights for studies in the fields of oxidative stress, cancer, and neurodegenerative diseases.
CHAC1 is a critical player in the cellular response to stress, particularly in the regulation of glutathione metabolism and redox signaling. Dysregulation of CHAC1 has been implicated in various diseases, including cancer and neurodegenerative disorders, highlighting its potential as a therapeutic target. By understanding the functions and mechanisms of CHAC1, researchers can uncover new opportunities for developing novel treatments and interventions for these conditions.
Product Name:
CHAC1 Rabbit Polyclonal Antibody
SKU:
CAB15584
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-222 of human CHAC1 (NP_077016.3).
This gene encodes a member of the gamma-glutamylcyclotransferase family of proteins. The encoded protein has been shown to promote neuronal differentiation by deglycination of the Notch receptor, which prevents receptor maturation and inhibits Notch signaling. This protein may also play a role in the unfolded protein response, and in regulation of glutathione levels and oxidative balance in the cell. Elevated expression of this gene may indicate increased risk of cancer recurrence among breast and ovarian cancer patients.
Purification Method:
Affinity purification
Gene ID:
79094
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse stomach, using CHAC1 Rabbit pAb (CAB15584) at 1:900 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
