The CGNL1 Polyclonal Antibody (PACO08387) is a valuable tool for researchers studying CGNL1, a protein involved in cellular processes related to immune function and cancer development. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the CGNL1 protein, this antibody enables the detection and analysis of CGNL1 in a variety of cell types, making it an ideal choice for studies in immunology and cancer biology.
CGNL1, also known as cingulin-like 1, is a key player in regulating cell-cell adhesion, cell signaling, and intracellular transport processes. Its role in immune regulation and cancer progression makes it a promising target for research aimed at understanding and treating diseases such as cancer, autoimmune disorders, and inflammatory conditions. Investigating the functions of CGNL1 is essential for developing targeted therapies that can modulate cellular processes in these disease contexts.
CGNL1: May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons. Defects in CGNL1 are a cause of aromatase excess syndrome (AEXS). A disorder characterized by an estrogen excess due to an increased aromatase activity. A chromosomal aberration inv(15)(q21.2;q21.3) has been found in patients with aromatase excess syndrome. The inversion moves the promoter of the CGNL1 gene into a 5-prime position in relation to the aromatase coding region. Belongs to the cingulin family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Cell adhesionChromosomal Location of Human Ortholog: 15q21.3
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the cingulin family. The encoded protein localizes to both adherens and tight cell-cell junctions and mediates junction assembly and maintenance by regulating the activity of the small GTPases RhoA and Rac1. Heterozygous chromosomal rearrangements resulting in association of the promoter for this gene with the aromatase gene are a cause of aromatase excess syndrome. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2011]
