The CGGBP1 Polyclonal Antibody (CAB4231) is a valuable tool for researchers studying the CGGBP1 protein, a key player in chromatin organization and gene expression regulation. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for various applications including Western blotting.CGGBP1, also known as CGG triplet repeat-binding protein 1, is involved in modulating gene transcription and maintaining chromatin structure. Its dysregulation has been linked to various human diseases, including neurodegenerative disorders and cancer.
By targeting the CGGBP1 protein, researchers can gain insights into its role in gene regulation and its potential as a therapeutic target for diseases.With its ability to detect and analyze CGGBP1 in different cell types, the CGGBP1 Polyclonal Antibody is a valuable tool for furthering research in molecular biology, epigenetics, and disease mechanisms. By understanding the functions of CGGBP1, researchers can potentially uncover new therapeutic strategies for treating diseases associated with chromatin and gene expression dysregulation.
Product Name:
CGGBP1 Rabbit Polyclonal Antibody
SKU:
CAB4231
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-167 of human CGGBP1 (NP_003654.3).
This gene encodes a CGG repeat-binding protein that primarily localizes to the nucleus. CGG trinucleotide repeats are implicated in many disorders as they often act as transcription- and translation-regulatory elements, can produce hairpin structures which cause DNA replication errors, and form regions prone to chromosomal breakage. CGG repeats are also targets for CpG methylation. In addition to its ability to bind CGG repeats and regulate transcription, this gene is believed to play a role in DNA damage repair and telomere protection. In vitro studies indicate this protein does not bind to methylated CpG sequences.
Purification Method:
Affinity purification
Gene ID:
8545
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CGGBP1 Rabbit pAb (CAB4231) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
