The CGB Antibody (PACO16021) is a superior tool for researchers studying the expression and function of Chorionic Gonadotropin Beta (CGB) protein. Raised in rabbits, this polyclonal antibody exhibits high reactivity with human samples, making it an excellent choice for Western blot applications. By specifically targeting the CGB protein, this antibody enables precise detection and analysis in a variety of cell types, making it an indispensable tool for investigations in reproductive biology and cancer research.CGB, a key protein in pregnancy and tumor development, plays a crucial role in regulating growth and differentiation in trophoblast cells.
Its aberrant expression has been linked to various reproductive disorders and cancer types, underscoring its importance as a potential biomarker and therapeutic target. By unraveling the mechanisms underlying CGB function, researchers can gain valuable insights into fertility, pregnancy complications, and oncogenesis, paving the way for novel diagnostic and treatment strategies in these areas.
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16021(CGB Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human placenta tissue, Primary antibody: PACO16021(CGB Antibody) at dilution 1/454, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes.
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO16021(CGB Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene is a member of the glycoprotein hormone β chain family and encodes the β 3 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common α subunit and an unique β subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The β subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone β subunit gene.
Synonyms:
chorionic gonadotropin, β polypeptide
UniProt Protein Function:
CGB: Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. Belongs to the glycoprotein hormones subunit beta family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:Secreted, signal peptide; Inhibitor; Secreted
Chromosomal Location of Human Ortholog: 19q13.32
NCBI Summary:
This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 8 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008]
