The cGAS Polyclonal Antibody (CAB8335) is a valuable tool for researchers studying the cGAS protein, a key player in the innate immune response to DNA viruses and intracellular bacteria. Produced in rabbits, this antibody is highly specific for human samples and has been validated for use in Western blot applications. It binds to cGAS, facilitating its detection and analysis in various cell types, making it an essential reagent for investigations in immunology and infectious disease research.cGAS, also known as cyclic GMP-AMP synthase, functions as a cytosolic DNA sensor, triggering signaling pathways that lead to the production of type I interferons and pro-inflammatory cytokines.
Its role in detecting viral and bacterial DNA highlights its importance in host defense mechanisms and immune surveillance. Research on cGAS has implications for understanding viral infections, autoimmune diseases, and potential therapeutic interventions that target the immune response.Overall, the cGAS Polyclonal Antibody is a valuable resource for scientists seeking to explore the intricate mechanisms of innate immunity and the role of cGAS in immune responses to DNA pathogens. Its high specificity and reliability make it a trusted tool for studying the intricate pathways involved in anti-viral and anti-bacterial immune defenses.
Product Name:
cGAS Rabbit Polyclonal Antibody
SKU:
CAB8335
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 401-501 of human CGAS(NP_612450.2).
Enables several functions, including 2',3'-cyclic GMP-AMP synthase activity; chromatin binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including cellular response to exogenous dsRNA; positive regulation of intracellular signal transduction; and regulation of defense response. Located in several cellular components, including cytosol; nucleus; and site of double-strand break.
Purification Method:
Affinity purification
Gene ID:
115004
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from HeLa cells using cGAS Rabbit pAb(CAB8335) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
