The CFLAR Polyclonal Antibody (CAB2555) is a valuable tool for researchers studying CFLAR, a key regulator of cell death and apoptosis. This antibody, produced in rabbits, exhibits high specificity and sensitivity in detecting CFLAR in human samples and is validated for use in Western blot applications. By binding to the CFLAR protein, this antibody allows for the precise detection and analysis of CFLAR expression in various cell types.CFLAR, also known as FLIP, plays a crucial role in modulating cell death pathways and maintaining cellular homeostasis.
Dysregulation of CFLAR expression has been implicated in various diseases, including cancer, autoimmune disorders, and neurodegenerative conditions. Research into CFLAR function is essential for understanding the mechanisms underlying these diseases and for developing targeted therapies.Overall, the CFLAR Polyclonal Antibody (CAB2555) provides researchers with a reliable tool to investigate the role of CFLAR in cell death pathways and disease pathology, offering valuable insights for the development of novel therapeutic strategies.
Product Name:
cFLIP Rabbit Polyclonal Antibody
SKU:
CAB2555
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 90-240 of human cFLIP (NP_003870.4).
The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists.
Purification Method:
Affinity purification
Gene ID:
8837
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of Jurkat cells, using cFLIP antibody (CAB2555) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
