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CFLAR Monoclonal Antibody [P5D8AT] (CPAB0564)

SKU:
CPAB0564
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Mouse
Isotype:
IgG3
Clone:
P5D8AT
Applications:
WB
ELISA
€149
Frequently bought together:

Description

system_update_alt Datasheet

CFLAR Monoclonal Antibody [P5D8AT] (CPAB0564)

The CFLAR Polyclonal Antibody (CPAB0564) is specifically designed for research involving CFLAR, a key regulator of apoptosis and inflammation. This antibody, raised in rabbits, is highly reactive with human samples and is validated for use in Western blot applications. It binds to the CFLAR protein, allowing for the detection and analysis of CFLAR in various cell types.CFLAR, also known as FLIP, is a critical player in the regulation of apoptosis, acting as an inhibitor of caspase-8 activation. Its role in controlling cell death pathways and inflammation makes it a crucial target for studies in immunology, cancer research, and other related fields.

Understanding the function of CFLAR can provide insights into diseases characterized by dysregulated cell death, such as cancer, autoimmune disorders, and neurodegenerative conditions.The CFLAR Polyclonal Antibody (CPAB0564) is a valuable tool for researchers looking to investigate the role of CFLAR in different biological processes and diseases. Its high reactivity and specificity make it an ideal choice for studies aiming to elucidate the mechanisms underlying cell death and inflammation regulation.

Product Name:CFLAR Antibody
Product Sku:CPAB0564
Size:5μg
Host Species:Mouse
Immunogen:Anti-human CFLAR mAb is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human CFLAR amino acids 1-376 purified from Ecoli.
Clone:P5D8AT.
Reactivity:Other bodies
Applications:Western Blot, ELISA
Purification Method:CFLAR antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG3
Background:CFLAR contains two death effector domains (DEDs) and a caspase-like domain. CFLAR may play a critical role between cell survival and cell death pathway in mammalian cells. CFLAR also interacts with adapter protein FADD and caspase-8 and -10, and potently inhibits apoptosis induced by all known death receptors DR3 (death receptor 3), TRAIL-R (TNF-related apoptosis-inducing ligand receptor) and TNFR1 (tumor necrosis factor receptor 1).
Synonyms:CASP8 and FADD-like apoptosis regulator, Cellular FLICE-like inhibitory protein, Caspase-eight-related protein, Caspase-like apoptosis regulatory protein, MACH-related inducer of toxicity, Caspase homolog, Inhibitor of FLICE, FADD-like antiapoptotic molecule 1, Usurpin, c-FLIP, Casper, CLARP, MRIT, CASH, I-FLICE, FLAME-1, CFLAR, CASP8AP1.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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