The Cofilin-2 Polyclonal Antibody (CAB8009) is a valuable tool for researchers studying cofilin-2, a protein involved in actin filament dynamics and cell cytoskeleton regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.Cofilin-2 plays a crucial role in cell motility, migration, and division, making it a key target for investigation in various biological processes. By binding specifically to cofilin-2, this antibody enables the detection and analysis of the protein in different cell types, making it well-suited for studies in cell biology, cancer research, and neurodegenerative diseases.
Understanding the function and regulation of cofilin-2 is essential for unraveling its role in cellular processes and disease pathways. The Cofilin-2 Polyclonal Antibody provides researchers with a reliable tool to explore the functions and mechanisms of cofilin-2, paving the way for new insights and potential therapeutic targets in various fields of research.
Product Name:
CFL2 Rabbit Polyclonal Antibody
SKU:
CAB8009
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-166 of human CFL2 (NP_068733.1).
This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
1073
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CFL2 antibody (CAB8009) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
