The Complement Factor I Polyclonal Antibody (CAB5623) is a valuable tool for researchers studying the complement system, a key component of the immune response. This antibody, produced in rabbits, is highly specific to human samples and is suitable for use in Western blot applications.Complement Factor I is an essential regulator of the complement cascade, which plays a critical role in host defense against pathogens and the clearance of immune complexes. Dysregulation of the complement system has been implicated in various diseases, including autoimmune disorders, inflammatory conditions, and cancer. By targeting Complement Factor I, researchers can gain insight into the mechanisms underlying these diseases and potentially develop new therapeutic strategies.
This Polyclonal Antibody binds specifically to Complement Factor I, allowing for precise detection and analysis in a variety of cell types. Its high reactivity and reliability make it an invaluable tool for investigations into the function and regulation of the complement system in health and disease. Whether studying immune responses, inflammatory pathways, or tumor microenvironments, the CAB5623 antibody is a versatile resource for advancing scientific understanding and potentially uncovering new therapeutic targets.
Product Name:
CFI Rabbit Polyclonal Antibody
SKU:
CAB5623
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 19-300 of human CFI (NP_000195.2).
This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uremic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immune deposits and age-related macular degeneration are other conditions associated with mutations of this gene.
Purification Method:
Affinity purification
Gene ID:
3426
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of Human serum, using CFI antibody (CAB5623) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
