CFHR5 Rabbit Polyclonal Antibody (CAB10367)
- SKU:
- CAB10367
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | CFHR5 Rabbit Polyclonal Antibody |
SKU: | CAB10367 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 450-569 of human CFHR5 (NP_110414.1). |
Sequence: | GPPP SINN GDTT SFPL SVYP PGST VTYR CQSF YKLQ GSVT VTCR NKQW SEPP RCLD PCVV SEEN MNKN NIQL KWRN DGKL YAKT GDAV EFQC KFPH KAMI SSPP FRAI CQEG KFEY PICE |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | FHR5; CFHL5; FHR-5; CFHR5D; CFHR5 |
Positive Sample: | HepG2,K-562,Mouse liver,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted. |
Calculated MW: | 64kDa |
Observed MW: | 75kDa |
This gene is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties, a region within repeats 5-7 having heparin binding and C reactive protein binding properties, and the C-terminal repeats being similar to a complement component 3 b (C3b) binding domain. This protein co-localizes with C3, binds C3b in a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been associated, but not causally linked, with two different forms of kidney disease: membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS).
Purification Method: | Affinity purification |
Gene ID: | 81494 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |