CFHR2 Antibody (PACO33384)
- SKU:
- PACO33384
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
CFHR2 Antibody (PACO33384)
The CFHR2 Polyclonal Antibody (PAC03384) is a reliable tool for researchers studying CFHR2, a protein involved in the regulation of the complement system. This antibody, produced in rabbits, is highly specific for human samples and is validated for use in Western blot applications. By binding to CFHR2, researchers can detect and analyze the protein in various cell types, making it an essential tool for studies in immunology and autoimmune research.CFHR2 is a crucial component in the complement system, playing a role in regulating the activation and amplification of complement proteins. Dysregulation of CFHR2 has been implicated in various inflammatory and autoimmune diseases, making it a promising target for therapeutic interventions.
By studying CFHR2 using this antibody, researchers can gain insights into its function and potential as a therapeutic target in conditions such as lupus, rheumatoid arthritis, and other autoimmune disorders.In conclusion, the CFHR2 Polyclonal Antibody (PAC03384) is a valuable tool for researchers investigating the role of CFHR2 in the complement system and its implications in immune-related diseases. Its high specificity and reliability make it a trusted reagent for Western blot applications, providing crucial data for advancing our understanding of immune regulation and autoimmune conditions.
| Antibody Name: | CFHR2 Antibody (PACO33384) |
| Antibody SKU: | PACO33384 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Complement factor H-related protein 2 protein (20-269AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: CFHR2 antibody at 2µg/ml Lane 1: Hela whole cell lysate Lane 2: 293T whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 31, 28 kDa Observed band size: 36 kDa . |
 | Immunohistochemistry of paraffin-embedded human liver tissue using PACO33384 at dilution of 1:100. |
| Background: | Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. Can associate with lipoproteins and may play a role in lipid metabolism. |
| Synonyms: | Complement factor H-related protein 2 (FHR-2) (DDESK59) (H factor-like 3) (H factor-like protein 2), CFHR2, CFHL2 FHR2 HFL3 |
| UniProt Protein Function: | CFHR2: Might be involved in complement regulation. Can associate with lipoproteins and may play a role in lipid metabolism. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 1q31.3 Cellular Component: extracellular region |
| NCBI Summary: | This gene belongs to a family of complement factor H-related genes (CFHR), which are clustered together with complement factor H gene on chromosome 1, and are involved in regulation of complement. Mutations in CFHR genes have been associated with dense deposit disease and atypical haemolytic-uraemic syndrome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2015] |
| UniProt Code: | P36980 |
| NCBI GenInfo Identifier: | 916404479 |
| NCBI Gene ID: | 3080 |
| NCBI Accession: | NP_001299601.1 |
| UniProt Secondary Accession: | P36980,Q14310, Q5T9T1, |
| UniProt Related Accession: | P36980 |
| Molecular Weight: | |
| NCBI Full Name: | complement factor H-related protein 2 isoform 2 |
| NCBI Synonym Full Names: | complement factor H related 2 |
| NCBI Official Symbol: | CFHR2Â Â |
| NCBI Official Synonym Symbols: | FHR2; HFL3; CFHL2Â Â |
| NCBI Protein Information: | complement factor H-related protein 2 |
| UniProt Protein Name: | Complement factor H-related protein 2 |
| UniProt Synonym Protein Names: | DDESK59; H factor-like 3; H factor-like protein 2 |
| Protein Family: | Complement factor H-related protein |
| UniProt Gene Name: | CFHR2Â Â |
| UniProt Entry Name: | FHR2_HUMAN |
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