CFH Rabbit Polyclonal Antibody (CAB13686)
- SKU:
- CAB13686
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
Product Name: | CFH Rabbit Polyclonal Antibody |
SKU: | CAB13686 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human Complement factor H (NP_004485.1). |
Sequence: | MSRS NRQK EYKC GDLV FAKM KGYP HWPA RIDE MPEA AVKS TANK YQVF FFGT HETA FLGP KDLF PYEE SKEK FGKP NKRK GFSE GLWE IENN PTVK ASGY QSSQ KKSC VEEP EPEP EAAE GDGD KKGN AEGS SDEE GKLV IDEP AKEK NEKG ALKR RAGD LLED SPKR PKEA ENPE GEEK EAAT LEVE RPLP MEVE KNST PSEP GSGR GPPQ EEEE EEDE EEEA TKED AEAP GIRD HESL |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | FH; HF; HF1; HF2; HUS; FHL1; AHUS1; AMBP1; ARMD4; ARMS1; CFHL3; Complement factor H |
Positive Sample: | Human plasma,Mouse plasma,Rat plasma |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted. |
Calculated MW: | 139kDa |
Observed MW: | 150kDa |
This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Purification Method: | Affinity purification |
Gene ID: | 3075 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |