The CFH Polyclonal Antibody (CAB13686) is a valuable tool for research involving the complement factor H (CFH) protein, which plays a crucial role in the regulation of the complement system. This antibody, generated in rabbits, specifically targets the CFH protein in human samples and is validated for use in Western blot applications.CFH is known for its ability to control the activation of the complement system, a key component of the immune response that helps to clear pathogens and damaged cells from the body. Dysregulation of the complement system, including abnormalities in CFH, has been implicated in various diseases, including age-related macular degeneration and atypical hemolytic uremic syndrome.
The CFH Polyclonal Antibody allows for the detection and analysis of CFH in different cell types, making it an ideal tool for studies in immunology, ophthalmology, and nephrology research. Understanding the role of CFH in the complement system is essential for developing targeted therapies for diseases associated with complement dysregulation.
Product Name:
CFH Rabbit Polyclonal Antibody
SKU:
CAB13686
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human Complement factor H (NP_004485.1).
This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Purification Method:
Affinity purification
Gene ID:
3075
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using Complement factor H Rabbit pAb (CAB13686) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
