CFB Rabbit Polyclonal Antibody (CAB13243)
- SKU:
- CAB13243
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
Product Name: | CFB Rabbit Polyclonal Antibody |
SKU: | CAB13243 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 80-420 of human Complement factor B (CFB) (NP_001701.2). |
Sequence: | GSWS TLKT QDQK TVRK AECR AIHC PRPH DFEN GEYW PRSP YYNV SDEI SFHC YDGY TLRG SANR TCQV NGRW SGQT AICD NGAG YCSN PGIP IGTR KVGS QYRL EDSV TYHC SRGL TLRG SQRR TCQE GGSW SGTE PSCQ DSFM YDTP QEVA EAFL SSLT ETIE GVDA EDGH GPGE QQKR KIVL DPSG SMNI YLVL DGSD SIGA SNFT GAKK CLVN LIEK VASY GVKP RYGL VTYA TYPK IWVK VSEA DSSN ADWV TKQL NEIN YEDH KLKS GTNT KKAL QAVY SMMS WPDD VPPE GWNR TRHV IILM TDGL HNMG GDPI TVID EIRD LLYI GKDR KNPR E |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:1000 - 1:2000 |
Synonyms: | BF; FB; BFD; GBG; CFAB; CFBD; PBF2; AHUS4; FBI12; H2-Bf; ARMD14; Complement factor B (CFB) |
Positive Sample: | Rat serum |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted. |
Calculated MW: | 86kDa |
Observed MW: | 100kDa |
This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.
Purification Method: | Affinity purification |
Gene ID: | 629 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |