The CFAP410 Polyclonal Antibody (PACO25352) is a valuable tool for researchers studying CFAP410, a protein involved in cilia and flagella formation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is optimized for use in Western blot applications. By targeting the CFAP410 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential resource for studies in cell biology and reproductive health.CFAP410, also known as cilia- and flagella-associated protein 410, plays a crucial role in cilia and flagella function, impacting various cellular processes such as motility and signaling.
Dysregulation of CFAP410 has been linked to ciliopathies and male infertility, highlighting its importance in reproductive biology and human health. By investigating the functions of CFAP410, researchers can gain insights into developmental disorders and potential therapeutic targets for treating related conditions.
Antibody Name:
CFAP410 Antibody (PACO25352)
Antibody SKU:
PACO25352
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Cilia- and flagella-associated protein 410 protein (1-200AA)
Immunohistochemistry of paraffin-embedded human gastric cancer using PACO25352 at dilution of 1:100.
Background:
Plays a role in cilia formation and/or maintenance (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987). Involved in DNA damage repair (PubMed:26290490).
Synonyms:
Cilia- and flagella-associated protein 410 (C21orf-HUMF09G8.5) (Leucine-rich repeat-containing protein 76) (YF5/A2), CFAP410, C21orf2, LRRC76
UniProt Protein Function:
C21orf2: 2 isoforms of the human protein are produced by alternative splicing.Protein type: Unknown functionChromosomal Location of Human Ortholog: 21q22.3Cellular Component: cytoplasm; mitochondrion; photoreceptor connecting cilium; plasma membraneMolecular Function: protein bindingBiological Process: cytoskeleton organization and biogenesis; regulation of cell shape
UniProt Protein Details:
NCBI Summary:
Four alternatively spliced transcript variants encoding four different isoforms have been found for this nuclear gene. All isoforms contain leucine-rich repeats. Three of these isoforms are mitochondrial proteins and one of them lacks the target peptide, so is not located in mitochondrion. This gene is down-regulated in Down syndrome (DS) brain, which may represent mitochondrial dysfunction in DS patients. [provided by RefSeq, Sep 2012]
