The CFAP100 Polyclonal Antibody (PAC035998) is a valuable tool for researchers studying CFAP100, a protein involved in cilia formation and function. This antibody, produced in rabbits, shows strong reactivity with human samples and has been validated for use in Western blot applications. By binding to the CFAP100 protein, this antibody allows for the detection and analysis of CFAP100 in various cell types, making it an essential reagent for research in biology and genetics.CFAP100 is a key player in the structure and function of cilia, tiny hair-like structures found on the surface of cells. Cilia play important roles in cell movement, signal transduction, and sensory functions.
Dysregulation of CFAP100 has been implicated in ciliary dysfunction-related diseases such as ciliopathies and respiratory disorders. Understanding the function of CFAP100 is crucial for advancing our knowledge of cilia biology and developing potential treatments for cilia-related disorders.Overall, the CFAP100 Polyclonal Antibody is a reliable tool for researchers seeking to explore the role of CFAP100 in cellular processes and diseases related to cilia dysfunction. Its high specificity and sensitivity in detecting CFAP100 make it an indispensable resource for studies in cell biology, genetics, and developmental biology.
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO35998 at dilution of 1:100.
Immunofluorescent analysis of HepG2 cells using PACO35998 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
May play a role in ciliary/flagellar motility by regulating the assembly and the activity of axonemal inner dynein arm.
Synonyms:
Cilia- and flagella-associated protein 100 (Coiled-coil domain-containing protein 37), CFAP100, CCDC37
UniProt Protein Function:
CCDC37: 2 isoforms of the human protein are produced by alternative splicing.Protein type: Unknown functionChromosomal Location of Human Ortholog: 3q21.3
