The CES1 Rabbit Monoclonal Antibody is a cutting-edge tool for researchers studying Carboxylesterase 1 (CES1), an enzyme involved in drug metabolism and detoxification processes in the liver and other tissues. This highly specific antibody, generated in rabbits, offers exceptional sensitivity and specificity in detecting CES1 protein levels in various cell types and tissues.CES1 is a critical enzyme involved in the metabolism of numerous drugs, including anti-cancer agents, analgesics, and antiviral medications. Understanding the expression and activity of CES1 is vital for predicting drug responses, optimizing dosages, and minimizing adverse effects in patients undergoing pharmacotherapy.
The CES1 Rabbit Monoclonal Antibody is validated for use in immunohistochemistry, Western blot, and other protein detection techniques, making it an invaluable tool for researchers in pharmacology, drug development, and personalized medicine. By enabling precise and reliable detection of CES1, this antibody can advance our understanding of drug metabolism pathways and facilitate the development of more effective and safer pharmacological interventions.
Product Name:
CES1 Rabbit Monoclonal Antibody
SKU:
CAB11478
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CES1 (P23141).
Hep G2,Mouse liver,Mouse kidney,Rat lung,Rat liver,Rat kidney
Conjugate:
Unconjugated
Cellular Localization:
Endoplasmic reticulum lumen.
Calculated MW:
63kDa
Observed MW:
63kDa
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
1066
Clone Number:
ARC0613
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using CES1 Rabbit mAb (CAB11478) at 1：1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
