The Ceruloplasmin Polyclonal Antibody (CAB7658) is a valuable tool for researchers studying ceruloplasmin, a multi-functional copper-binding protein involved in iron metabolism and antioxidant activity. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for various research applications.Ceruloplasmin, a ferroxidase enzyme, plays a vital role in iron homeostasis by facilitating the conversion of ferrous iron to ferric iron, which is essential for iron transport and storage in the body. Additionally, ceruloplasmin has antioxidant properties, scavenging free radicals and protecting cells from oxidative damage.By targeting ceruloplasmin, researchers can investigate its role in conditions such as Wilson's disease, where mutations in the ceruloplasmin gene lead to copper accumulation and toxicity.
Furthermore, studies involving ceruloplasmin can provide insights into the mechanisms underlying iron metabolism disorders, neurodegenerative diseases, and cardiovascular conditions.The Ceruloplasmin Polyclonal Antibody (CAB7658) enables precise detection and analysis of ceruloplasmin in various sample types, making it a valuable resource for scientific investigations in fields such as biochemistry, molecular biology, and clinical research. Gain a deeper understanding of ceruloplasmin's functions and implications by incorporating this antibody into your experimental workflows.
Product Name:
Ceruloplasmin Rabbit Polyclonal Antibody
SKU:
CAB7658
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 366-572 of human Ceruloplasmin (NP_000087.1).
The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
1356
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Ceruloplasmin Antibody (CAB7658) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
