The CERS6 Polyclonal Antibody (PAC019930) is a valuable tool for researchers studying the CERS6 protein, a key enzyme involved in ceramide synthesis. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in various applications, including Western blotting. By binding specifically to the CERS6 protein, this antibody enables accurate detection and analysis in different cell types, making it an ideal choice for studies in lipid metabolism and cancer research.CERS6, also known as ceramide synthase 6, plays a crucial role in the biosynthesis of ceramides, which are important lipid molecules involved in various cellular processes, including cell signaling, apoptosis, and inflammation.
Dysregulation of ceramide metabolism has been implicated in numerous diseases, such as cancer, neurodegenerative disorders, and metabolic syndromes. Therefore, investigating the function of CERS6 and its impact on cellular pathways is essential for developing targeted therapies and understanding disease mechanisms.
Antibody Name:
CERS6 Antibody (PACO19930)
Antibody SKU:
PACO19930
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human CERS6
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19930(CERS6 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO19930(CERS6 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The LASS (longevity assurance homolog) family members are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1, LASS2, LASS3, LASS4, LASS5 and LASS6) and they all are involved in sphingolipid synthesis. LASS6 is a widely expressed 384 amino acid, endoplasmic reticulum, multi-pass membrane protein. On the luminal side of the endoplasmic reticulum membrane, the N-terminal asparagine residue is glycosylated. In cells deficient for CLN9, LASS6 corrects growth and apoptosis, and increases the levels of short ceramide species, such as C14:0- and C16:0-ceramides.
Synonyms:
ceramide synthase 6
UniProt Protein Function:
LASS6: May be involved in sphingolipid synthesis or its regulation.Protein type: Membrane protein, integral; DNA-binding; Membrane protein, multi-passChromosomal Location of Human Ortholog: 2q24.3Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; membraneMolecular Function: sphingosine N-acyltransferase activityBiological Process: ceramide biosynthetic process; sphingolipid biosynthetic process
