The CERS4 Polyclonal Antibody (PACO01014) is a valuable tool for researchers studying CERS4, a key enzyme involved in ceramide synthesis. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blotting applications. By targeting the CERS4 protein, this antibody allows for the detection and analysis of CERS4 expression in a variety of cell types.CERS4 is essential for the production of ceramides, which play crucial roles in cell signaling and maintaining cellular homeostasis. Dysregulation of ceramide metabolism has been linked to various diseases, including cancer, diabetes, and neurodegenerative disorders.
By studying CERS4 expression and function, researchers can gain insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets.Overall, the CERS4 Polyclonal Antibody is a valuable tool for researchers interested in investigating the role of ceramide metabolism in health and disease. Its high specificity and sensitivity make it ideal for a wide range of research applications in molecular biology, biochemistry, and pharmacology.
Antibody Name:
CERS4 Antibody
Antibody SKU:
PACO01014
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human LASS4.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Lass4: May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner.Protein type: Membrane protein, multi-pass; Membrane protein, integral; DNA-bindingChromosomal Location of Human Ortholog: 19p13.2Cellular Component: endoplasmic reticulum; endoplasmic reticulum membraneMolecular Function: sphingosine N-acyltransferase activityBiological Process: ceramide biosynthetic process; sphingolipid biosynthetic process
