The CERS3 Polyclonal Antibody (PACO58268) is a valuable tool for researchers studying CERS3, a protein involved in ceramide synthesis and metabolism. This antibody, produced in rabbits, exhibits strong reactivity with human samples and is validated for use in various applications, with a specific focus on Western blotting.CERS3 is a key enzyme in the synthesis of ceramides, which play essential roles in cell signaling, apoptosis, and lipid metabolism. Dysregulation of ceramide levels has been linked to various diseases, including cancer, diabetes, and neurodegenerative disorders.
By targeting CERS3, researchers can explore the impact of ceramide metabolism on these conditions and potentially identify new therapeutic targets.The CERS3 Polyclonal Antibody allows for the detection and analysis of CERS3 protein levels in different cell types, providing insights into its role in lipid biology and disease pathology. Its versatility and specificity make it an ideal choice for studies investigating ceramide synthesis and its implications in health and disease.
Antibody Name:
CERS3 Antibody (PACO58268)
Antibody SKU:
PACO58268
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:5000
Species Reactivity:
Human, Mouse
Immunogen:
Recombinant Human Ceramide synthase 3 protein (59-134AA)
Western Blot. Positive WB detected in: Mouse heart tissue. All lanes: CERS3 antibody at 3.6µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 47 kDa. Observed band size: 47 kDa.
Background:
Has (dihydro)ceramide synthesis activity with relatively broad substrate specificity, but a preference for C18:0 and other middle- to long-chain fatty acyl-CoAs (By similarity). It is crucial for the synthesis of very long-chain ceramides in the epidermis, to maintain epidermal lipid homeostasis and terminal differentiation.
Has (dihydro)ceramide synthesis activity with relatively broad substrate specificity, but a preference for C18:0 and other middle- to long-chain fatty acyl-CoAs (). It is crucial for the synthesis of very long-chain ceramides in the epidermis, to maintain epidermal lipid homeostasis and terminal differentiation.
UniProt Protein Details:
NCBI Summary:
This gene is a member of the ceramide synthase family of genes. The ceramide synthase enzymes regulate sphingolipid synthesis by catalyzing the formation of ceramides from sphingoid base and acyl-coA substrates. This family member is involved in the synthesis of ceramides with ultra-long-chain acyl moieties (ULC-Cers), important to the epidermis in its role in creating a protective barrier from the environment. The protein encoded by this gene has also been implicated in modification of the lipid structures required for spermatogenesis. Mutations in this gene have been associated with male fertility defects, and epidermal defects, including ichthyosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
