CERS1 Antibody (PACO54854)
- SKU:
- PACO54854
- Product Type:
- Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
CERS1 Antibody (PACO54854)
The CERS1 Polyclonal Antibody (PACO54854) is a valuable tool for researchers studying CERS1, an enzyme involved in sphingolipid metabolism and cellular signaling pathways. This antibody, produced in rabbits, has high specificity for human samples and has been validated for use in Western blot applications. CERS1 plays a key role in the generation of ceramides, which are essential components of cell membranes and have diverse functions in cell growth, metabolism, and apoptosis. Dysregulation of CERS1 has been implicated in various diseases, including cancer, metabolic disorders, and neurodegenerative diseases.
By targeting the CERS1 protein, this antibody allows for accurate detection and analysis of CERS1 expression in different cell types, providing valuable insight into its role in cellular processes and disease development. Researchers in the fields of lipid metabolism, cell biology, and disease biology will find this antibody to be a valuable tool in their studies.
| Antibody Name: | CERS1 Antibody (PACO54854) |
| Antibody SKU: | PACO54854 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200 |
| Species Reactivity: | Human, Rat |
| Immunogen: | Recombinant Human Ceramide synthase 1 protein (1-52AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Rat brain tissue, Rat heart tissue. All lanes: CERS1 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 40, 38 kDa. Observed band size: 40 kDa. |
 | Immunohistochemistry of paraffin-embedded human brain tissue using PACO54854 at dilution of 1:100. |
| Background: | May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid, donor (N-linked stearoyl- (C18) ceramide) in a fumonisin B1-independent manner (By similarity). |
| Synonyms: | Ceramide synthase 1 (CerS1) (LAG1 longevity assurance homolog 1) (Longevity assurance gene 1 protein homolog 1) (Protein UOG-1), CERS1, LAG1 LASS1 UOG1 |
| UniProt Protein Function: | Function: May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked stearoyl- (C18) ceramide) in a fumonisin B1-independent manner By similarity.Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity. Isoform 1: Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity. Golgi apparatus membrane; Multi-pass membrane protein By similarity. Note: Isoform 1 may recycle from the Golgi to the endoplasmic reticulum.Miscellaneous: This protein is produced by a bicistronic gene which also produces the GDF1 protein from a non-overlapping reading frame.Sequence similarities: Contains 1 TLC (TRAM/LAG1/CLN8) domain. |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site that is cleaved to produce a mature protein containing seven conserved cysteine residues. Members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in yeast suggest that the encoded protein is involved in aging. This protein is transcribed from a monocistronic mRNA as well as a bicistronic mRNA, which also encodes growth differentiation factor 1. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P27544 |
| NCBI GenInfo Identifier: | 11641421 |
| NCBI Gene ID: | 10715 |
| NCBI Accession: | NP_067090.1 |
| UniProt Secondary Accession: | P27544 |
| UniProt Related Accession: | P27544 |
| Molecular Weight: | 39.5 kDa |
| NCBI Full Name: | ceramide synthase 1 isoform 1 |
| NCBI Synonym Full Names: | ceramide synthase 1 |
| NCBI Official Symbol: | CERS1Â Â |
| NCBI Official Synonym Symbols: | LAG1; UOG1; LASS1Â Â |
| NCBI Protein Information: | ceramide synthase 1; protein UOG-1; upstream of GDF1; longevity assurance gene 1 protein homolog 1; longevity assurance (LAG1, S. cerevisiae) homolog 1 |
| UniProt Protein Name: | Ceramide synthase 1 |
| UniProt Synonym Protein Names: | LAG1 longevity assurance homolog 1; Longevity assurance gene 1 protein homolog 1; Protein UOG-1 |
| Protein Family: | Embryonic growth/differentiation factor |
| UniProt Gene Name: | CERS1Â Â |
| UniProt Entry Name: | CERS1_HUMAN |
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