The CERS1 Antibody (PAC019924) is a valuable tool for researchers studying ceramide synthase 1 (CERS1), an enzyme involved in the biosynthesis of ceramides, essential components of cell membrane structure and signaling. This polyclonal antibody, generated in rabbits, has high specificity for human samples and is validated for use in Western blot applications. By targeting the CERS1 protein, this antibody enables the detection and analysis of CERS1 in various cell types, making it ideal for investigations in lipid metabolism, cell signaling, and related pathways.CERS1 is a key player in sphingolipid metabolism, with implications in cell proliferation, apoptosis, and response to cellular stress.
Dysregulation of CERS1 has been linked to various diseases, including cancer, neurodegenerative disorders, and metabolic syndromes. By studying the expression and activity of CERS1, researchers can gain insights into the role of ceramides in disease pathogenesis and potentially identify novel targets for therapeutic intervention. This antibody offers a valuable tool for unraveling the complex biology of CERS1 and its implications in health and disease.
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO19924(CERS1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hepg2 cells, hela cells, Primary antibody: PACO19924(CERS1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO19924(CERS1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-β superfamily. This group of proteins is characterized by a polybasic proteolytic processing site that is cleaved to produce a mature protein containing seven conserved cysteine residues. Members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in yeast suggest that the encoded protein is involved in aging.
Synonyms:
ceramide synthase 1
UniProt Protein Function:
Function: May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked stearoyl- (C18) ceramide) in a fumonisin B1-independent manner By similarity.Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity. Isoform 1: Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity. Golgi apparatus membrane; Multi-pass membrane protein By similarity. Note: Isoform 1 may recycle from the Golgi to the endoplasmic reticulum.Miscellaneous: This protein is produced by a bicistronic gene which also produces the GDF1 protein from a non-overlapping reading frame.Sequence similarities: Contains 1 TLC (TRAM/LAG1/CLN8) domain.
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site that is cleaved to produce a mature protein containing seven conserved cysteine residues. Members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in yeast suggest that the encoded protein is involved in aging. This protein is transcribed from a monocistronic mRNA as well as a bicistronic mRNA, which also encodes growth differentiation factor 1. [provided by RefSeq, Jul 2008]