The CERK Polyclonal Antibody (CAB15889) is a valuable tool for researchers studying the role of CERK (Ceramide Kinase) in cellular signaling pathways. CERK is a key enzyme involved in the metabolism of ceramide, a lipid molecule with important functions in cell growth, differentiation, and apoptosis. This polyclonal antibody, generated in rabbits, has been validated for use in various applications, including Western blotting and immunohistochemistry. It specifically binds to the CERK protein, allowing for the detection and analysis of CERK expression in different cell types and tissues.Research on CERK has implications in various fields, including cancer biology, immunology, and neurobiology.
Dysregulation of ceramide metabolism has been linked to the development of cancer, neurodegenerative diseases, and inflammation. By studying the activity and regulation of CERK, researchers can gain insights into these disease processes and potentially identify new therapeutic targets.Overall, the CERK Polyclonal Antibody provides a reliable tool for investigating the functions of CERK and its potential involvement in various physiological and pathological processes. Its high reactivity and specificity make it a valuable resource for researchers working in diverse areas of biomedical research.
Product Name:
CERK Rabbit Polyclonal Antibody
SKU:
CAB15889
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 400 to the C-terminus of human CERK (NP_073603.2).
CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation (Kim et al., 2006 [PubMed 16488390]).
Purification Method:
Affinity purification
Gene ID:
64781
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CERK Rabbit pAb (CAB15889) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
