The CEP97 Polyclonal Antibody (PACO16016) is a versatile tool for researchers studying CEP97, a protein involved in centrosome duplication and cell cycle regulation. This antibody, produced in rabbits, exhibits high specificity and sensitivity in detecting CEP97 in human samples, making it suitable for use in Western blotting and other applications.CEP97 is essential for centrosome function, with dysregulation of its expression linked to abnormalities in cell division and potential implications in cancer development. By targeting CEP97 with this antibody, researchers can investigate its role in various cellular processes and disease states, providing valuable insights for understanding and potentially targeting centrosome-related disorders.
Whether studying cell cycle dynamics, centrosome biology, or cancer development, the CEP97 Polyclonal Antibody offers a reliable tool for exploring the functions and significance of CEP97 in research settings. Its high reactivity and specificity make it a valuable addition to any immunological or cellular biology study focused on centrosome biology.
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO16016(CEP97 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: PC3 cells, lovo cells, Primary antibody: PACO16016(CEP97 Antibody) at dilution 1/750, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO16016(CEP97 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
Background:
Centrosomal protein of 97 kDa (Cep97), also known as leucine-rich repeat and IQ domain-containing protein 2 (LRRIQ2), is a protein that in humans is encoded by the CEP97 gene. Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome. Interacts with CALM1, CEP76 and CCP110. Via its interaction with CCP110, may indirectly interact with HERC2 and NEURL4. Interacts with KIF24.
Synonyms:
centrosomal protein 97kDa
UniProt Protein Function:
LRRIQ2: Collaborates with CCP110, being involved in the suppression of a cilia assembly program. Required for correct spindle formation and has a role in cytokinesis. Required for recruitment of CCP110 to the centrosome. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 3q12.3Cellular Component: centrosome; protein complex; cytoplasm; microtubule organizing center; cytosolMolecular Function: calmodulin binding; protein bindingBiological Process: cell projection organization and biogenesis; organelle organization and biogenesis
