The CEP76 Polyclonal Antibody (PAC039974) is a valuable tool for researchers studying CEP76, a protein involved in centrosome duplication and cell division. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot and immunofluorescence applications. By binding to CEP76, the antibody enables precise detection and analysis of this important protein in various cell types.CEP76 is a key player in the regulation of centrosome function, a vital process in cell division and genome stability. Dysregulation of CEP76 has been linked to various diseases, including cancer and neurodevelopmental disorders.
By studying CEP76 with the help of this antibody, researchers can gain insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets.In summary, the CEP76 Polyclonal Antibody (PAC039974) is a powerful tool for investigating the role of CEP76 in cellular processes and disease pathogenesis. Its high specificity and versatility make it an excellent choice for research in cell biology, oncology, and developmental biology.
Western blot. All lanes: CEP76 antibody at 0.5µg/ml + 293T whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 75, 66, 30 kDa. Observed band size: 75 kDa.
Immunohistochemistry of paraffin-embedded human colon cancer using PACO39974 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human breast cancer using PACO39974 at dilution of 1:100.
Background:
Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication.
Synonyms:
Centrosomal protein of 76 kDa (Cep76), CEP76, C18orf9
UniProt Protein Function:
CEP76: Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication. Belongs to the CEP76 family. 3 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 18p11.21Cellular Component: centriole; centrosome; cytosol; protein complexMolecular Function: protein bindingBiological Process: G2/M transition of mitotic cell cycle; mitotic cell cycle; organelle organization and biogenesis; regulation of centriole replication
UniProt Protein Details:
NCBI Summary:
This gene encodes a centrosomal protein which regulates centriole amplification by limiting centriole duplication to once per cell cycle. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
