The CEP72 Polyclonal Antibody (PACO45064) is a powerful tool for researchers studying the CEP72 protein, a key player in centrosome biology and cell division. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it an ideal choice for various experimental applications, including Western blotting and immunofluorescence.CEP72 is essential for proper centrosome duplication and cell division, making it a crucial target for research in the fields of cell biology and oncology. Dysregulation of CEP72 has been linked to abnormal cell division and cancer development, highlighting its importance in understanding disease mechanisms and potential therapeutic strategies.
By using the CEP72 Polyclonal Antibody, researchers can analyze the expression and localization of CEP72 in different cell types and conditions, providing valuable insights into its function and potential role in disease progression. This antibody is a valuable tool for advancing knowledge in centrosome biology and exploring new avenues for cancer therapy research.
Antibody Name:
CEP72 Antibody (PACO45064)
Antibody SKU:
PACO45064
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Centrosomal protein of 72 kDa protein (200-460AA)
Form:
Liquid
Storage Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method:
Antigen Affinity Purified
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemistry of paraffin-embedded human testis tissue using PACO45064 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human cervical cancer using PACO45064 at dilution of 1:100.
Background:
Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs). Involved in centriole duplication. Required for CDK5RAP22, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2.
Synonyms:
Centrosomal protein of 72 kDa (Cep72), CEP72, KIAA1519
UniProt Protein Function:
CEP72: Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ/PLK1S1, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs). Belongs to the CEP72 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Microtubule-bindingChromosomal Location of Human Ortholog: 5p15.33Cellular Component: centrosome; cytosolMolecular Function: protein bindingBiological Process: centriole replication; G2/M transition of mitotic cell cycle; gamma-tubulin complex localization; spindle organization and biogenesis
UniProt Protein Details:
NCBI Summary:
The product of this gene is a member of the leucine-rich-repeat (LRR) superfamily of proteins. The protein is localized to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. [provided by RefSeq, Jul 2008]
