The CEP43 Monoclonal Antibody is a valuable tool for researchers studying CEP43, a protein involved in cell division and cilia formation. This antibody, produced through monoclonal technology, has high specificity and sensitivity for detecting CEP43 in various biological samples. It is validated for use in immunofluorescence and immunohistochemistry applications, allowing for precise localization and visualization of CEP43 within cells.CEP43 is known to play a crucial role in centriole biogenesis and cilia assembly, making it essential for proper cell division and signaling processes.
Dysregulation of CEP43 has been associated with ciliopathies and other genetic disorders, highlighting its importance in human health and disease. By studying the function and localization of CEP43 using this monoclonal antibody, researchers can gain insights into its cellular functions and potential therapeutic targets for cilia-related diseases.
Product Name:
CEP43 Monoclonal Antibody
SKU:
CAB21074
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 300-399 of human CEP43 (NP_008976.1).
This gene encodes a largely hydrophilic centrosomal protein that is required for anchoring microtubules to subcellular structures. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. Alterations in this gene may also be associated with Crohn's disease, Graves' disease, and vitiligo. Alternatively spliced transcript variants that encode different proteins have been identified.
Purification Method:
Affinity purification
Gene ID:
11116
Clone Number:
ARC2913
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Immunofluorescence analysis of HeLa cells using CEP43 Rabbit mAb (CAB21074) at dilution of 1:50 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
