The CEP41 Polyclonal Antibody (PACO05783) is a valuable tool for researchers studying CEP41, a protein associated with ciliary function and centrosome organization. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the CEP41 protein, this antibody enables researchers to detect and analyze its expression in various cell types, making it ideal for research in cell biology and genetics.
CEP41, also known as Centrosomal protein of 41 kDa, plays a crucial role in maintaining proper cilia and centrosome function, which are essential for cell division and signaling. Dysregulation of CEP41 has been implicated in ciliopathies and other genetic disorders affecting cellular processes. By studying the function of CEP41, researchers can gain insights into these diseases and potentially develop targeted therapies to correct underlying defects.
Antibody Name:
CEP41 Antibody (PACO05783)
Antibody SKU:
PACO05783
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:40000, IHC:1:100-1:300
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from the Internal region of human CEP41.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
CEP41; TSGA14; Centrosomal protein of 41 kDa; Cep41; Testis-specific gene A14 protein
UniProt Protein Function:
TSGA14: Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating to the transport of TTLL6, a tubulin polyglutamylase, between the basal body and the cilium. Defects in CEP41 are the cause of Joubert syndrome type 15 (JBTS15). JBTS15 is an autosomal recessive disorder presenting with cerebellar ataxia, oculomotor apraxia, hypotonia, neonatal breathing abnormalities and psychomotor delay. Neuroradiologically, it is characterized by cerebellar vermian hypoplasia/aplasia, thickened and reoriented superior cerebellar peduncles, and an abnormally large interpeduncular fossa, giving the appearance of a molar tooth on transaxial slices (molar tooth sign). Additional variable features include retinal dystrophy, renal disease, liver fibrosis and polydactyly. Genetic variations in CEP41 may be associated with susceptibility to autism. Belongs to the CEP41 family. 5 isoforms of the human protein are produced by alternative splicing.Protein type: Unknown functionChromosomal Location of Human Ortholog: 7q32Cellular Component: centriole; centrosome; membrane; cytosolMolecular Function: protein bindingBiological Process: protein polyglutamylation; protein transport; organelle organization and biogenesis; cilium biogenesis; mitotic cell cycle; G2/M transition of mitotic cell cycleDisease: Joubert Syndrome 15; Joubert Syndrome 1
UniProt Protein Details:
NCBI Summary:
This gene encodes a centrosomal and microtubule-binding protein which is predicted to have two coiled-coil domains and a rhodanese domain. In human retinal pigment epithelial cells the protein localized to centrioles and cilia. Mutations in this gene have been associated with Joubert Syndrome 15; an autosomal recessive ciliopathy and neurological disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
