The CEP152 Antibody (PAC02742) is a valuable tool for researchers studying the centrosome protein CEP152. This antibody, raised in rabbits, is highly specific and reactive with human samples, making it ideal for use in various research applications such as immunofluorescence and Western blotting.CEP152 is a key player in centriole duplication and plays a crucial role in cell division and genome stability. Dysregulation of CEP152 has been linked to various human diseases, including cancer and genetic disorders.
By targeting CEP152 with this antibody, researchers can explore its function and potential implications in disease pathology.With its high specificity and versatility, the CEP152 Antibody (PAC02742) is a valuable tool for scientists studying cell division, centrosome biology, and related disease mechanisms. By enabling the detection and analysis of CEP152 in various cell types, this antibody contributes to advancements in biomedicine and drug discovery.
Antibody Name:
CEP152 Antibody
Antibody SKU:
PACO02742
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from the Internal region of human CEP152.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
CEP152; KIAA0912; Centrosomal protein of 152 kDa; Cep152
UniProt Protein Function:
Necessary for centrosome duplication; the function seems also to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation (PubMed:21059844, PubMed:20852615). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (PubMed:24997597). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (). Overexpression of CEP152 can drive amplification of centrioles (PubMed:20852615).
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein that is thought to be involved with centrosome function. Mutations in this gene have been associated with primary microcephaly (MCPH4). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]
